Ontario delays implementation of pharma transparency rules

Rules transparency and political accountability

Rules of allocation and redistribution in the public sector are often less contingent on available information than normative theory would suggest. This paper offers a political economy explanation. Under different rules, even if the observable outcomes of policies remain the same, the informational content which can be extracted by these observations is different. Less contingent rules allow c...

The Non-Transparency of Timeless Rules

We address fully optimal and optimal rules under a timeless perspective. We note that the Currie/Levine representation of the optimal rule is not necessarily determinate, which leads us to a result that shows that the optimal rule may be written in multiple ways, and cannot therefore be estimated by econometricians. We show that this problem cannot be resolved by appeal to robustly optimal poli...

Implementation Rules

Implementation of Quantitative and Systems Pharmacology in Large Pharma

Quantitative and systems pharmacology concepts and tools are the foundation of the model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment through significant cost avoidance. Critical f...

Good pharma? Bad pharma? Better pharma.